In the MCU/Marvel with the Omnitrix/Ultimatrix - Chapter 42: Spiderman

Lyra Shedd faced a brutal betrayal—her grandfather violently stole her superpower and handed it to her nemesis; her beloved younger brother, in his stupidity, leaked their only hidden assets to her enemies.Once a genius, she was reduced to nothing, drifting in the sea of stars.During her most agonizing years, she finally accepted the fact that her family didn't love her. Realizing she had nothing left to lose, she decided to throw off all moral restraints and become a villain!On her journey of revenge, she encountered many handsome men—but to a cold-blooded villain, they were nothing but tools for her vengeance!This time, she would make all those who pushed her to the brink tremble and scream for mercy!

Betrayed by his sister. Betrayed by chosen one's humanity. Betrayed by the Gods.That was how the life of Leonard, the Defier of Fate and the world’s greatest heretic, came to an end.When demons invaded human lands, he received a revelation from the Goddess. She commanded him to act as a spy, to infiltrate the enemy ranks and expose their secrets for humanity’s sake.To fulfill this mission, he had to sacrifice a part of his soul. He accepted a demonic contract, surrendered his soul, and became a demonic human. Risking everything, he provided critical information to the humans and helped them turn the tide of battle.But then, he had a shocking discovery.The war was nothing but a gambit between various gods and before he could act, the war was stopped out of nowhere.In an unexpected turn, humans and demons put aside their hatred and signed a peace treaty.Before Leonard could make sense of it, he was betrayed. Both demons and humans joined hands to kill him.“Fuck! If there is a next life, I swear I will tear you gods apart!”With this scream, he thought his suffering was finally over.But…When he opened his eyes again, he found himself in the body of Kael Veydrin, the son of the Grand Duke of the Heizen Empire. But this new life was no different from the last.His sister wanted to get rid of him.Born with clogged vessels and no talent, he was nothing but a disappointment.A subject of fun and ridicule among the fellow nobles.Despite rebirth, nothing seems to change.The cursed fate.The distorted history smearing his name.A world that was against him.Leonard, now assuming the identity of Kael, let out a low chuckle.“Don’t worry, Kael. I will have revenge for both of us.”“They called me heretic right? I will show them how a true fucking heretic acts.”Follow Kael's journey, as he fights against the fates and injustices to drag the ones ruling above.

The scum’s or villain’s long road of transformation was tentatively set to the world:
The abandonment of the educated youth’s wife (Completed)
The hidden marriage of the scum film emperor (Completed)
The best brother in the world (Completed)
The Phoenix male who destroy the bridge after crossing the river (Completed)
The treasonous general (Completed)
I’m an honest man (Completed)
To become the top scorer in the School of Agriculture (Completed)
The soft rice man’s self-cultivation (Completed)
The whole world is reborn (Completed)
I want to survive on a desert island (Completed)
The stallion male who has seized the opportunity (Completed)
The perverted self-salvation (Completed)
The spring of the loafer (Completed)
The misplaced life (Completed)
The miser career (Completed)
The ghost is out of feeling (Completed)
The Queen’s favorite husband (Completed)
The vicious girl with her godfather (Completed)
I want to be a good person (Completed)
I does not tear up the family (Completed)
The perverted common plant (Completed)
The Mary Sue’s men (Completed)
Every time I was reborn, someone wants to kill me (Completed)
The old people’s counterattack path (Completed)
The global evolution (Completed)
When I became a net red (Completed)
For you, good person (Completed)
His heart had white moonlight (Completed)

- Description from Novelupdates

Su Wen transmigrated and became the Prime Minister’s son, possessing both power and money.